Scientific Breakthrough Reveals That Two Common Herbs Could Be Groundbreaking In Alzheimer’s Treatment

Recently, scientists have discovered that the common herbs rosemary and sage might help treat memory loss associated with Alzheimer’s disease. Research has found that the herbs produce carnosic acid, a natural anti-inflammatory and antioxidant. Scripps Research has created a synthesized, stable form (diAcCA) that can be instrumental in developing an Alzheimer’s treatment.

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Carnosic acid stimulates enzymes in the body’s natural defense system. In its pure form, it is too unstable for use in medications. The synthetic version, diAcCA, converts to carnosic acid in the stomach, allowing absorption into the bloodstream.

So far, testing has involved mice, where therapeutic doses have enhanced memory and synaptic density. Early results point to the possibility that this Alzheimer’s treatment counteracts cognitive decline. The drug works by combatting inflammation. Inflammation activates the synthetic version, which begins to fight the inflammation, limiting the activity area to where memory damage occurs. The selectiveness limits potential side effects that occur with natural carnosic acid.

Senior author and professor Stuart Lipton, MD, PhD, says, “By combating inflammation and oxidative stress with this diAcCA compound, we actually increased the number of synapses in the brain.” He added, “We did multiple different tests of memory, and they were all improved with the drug, and it didn’t just slow down the decline; it improved virtually back to normal.”

Researchers think the innovative diAcCA will complement current Alzheimer’s treatments, increasing their efficacy and decreasing side effects. Due to its high safety profile, there is hope of fast-tracking diAcCA for clinical trials. The synthetic may also benefit other treatment programs for heart disease, type 2 diabetes, and Parkinson’s.

Although it will be some time before this Alzheimer’s treatment is available, it offers new hope for families dealing with this disease.

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